Histamine in Inflammation

1. One Hundred Years of Histamine Research Katherine Figueroa and Nigel ShankleyAbstractIntroductionExploring the Physiological Effects of HistamineThe First AntihistaminesPharmacological Definition of Histamine H1 and H2 ReceptorsPharmacological Definition of the Histamine H3 ReceptorPharmacological Definition of the Histamine H4 ReceptorThe Molecular Biological Characterization of Histamine ReceptorsAlternative Intracellular Signaling of Histamine ReceptorsGenerations of Histamine Targeted Genetically Modified MiceConclusion2. Molecular Pharmacology of the Four Histamine ReceptorsGerold Bongers, Iwan de Esch and Rob LeursAbstractThe Discovery of the Four Histamine Receptors: An Historical OverviewHistamine Receptors, Signal Transduction and Their LigandsThe Histamine H1 Receptor and Its LigandsThe Histamine H2 Receptor and Its LigandsThe Histamine H3 Receptor and Its LigandsThe Histamine H4 Receptor and Its LigandsConclusion3. Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient MiceHiroshi OhtsuAbstractIntroductionHDC Transcriptional RegulationEpigenetic Regulation of HDC Gene Expressionl?Histidine Decarboxylase Gene Knockout MiceHistamine and ImmunityHistamine in Wound HealingHistamine in MalariaHistamine in Crohn’sDiseaseHistamine in Allergic Bronchial AsthmaHistamine in Systemic Anaphylaxis ModelHistamine in AtherosclerosisHistamine Uptake into and Release from Histamine Producing CellsConclusion4. Histamine in Allergic Rhinitis Thomas Taylor?ClarkAbstractIntroductionHistamine and the Early Phase Response in Allergic RhinitisH1 Receptors: Sensory Nerve Activation and Central ReflexesH1 Receptors and the Nasal VasculatureOther Histamine Receptors in the Early Phase ResponseHistamine Receptors and Immune ModulationConclusion5. The Role of Histamine in Ocular Allergy Masaharu Ohbayashi, Bita Manzouri, Kei Morohoshi, Ken Fukuda and Santa J.OnoAbstractIntroductionClinical Manifestations of Ocular AllergyCurrent Treatments for Ocular AllergyAllergic Responses in the ConjunctivaMast Cells in the ConjunctivaHistamine in the ConjunctivaHistamine and the Conjunctival BarrierHistamine Receptors in the ConjunctivaTissue?Specific Roles of Histamine ReceptorsConclusion6. The Role of Histamine in Asthma Paul J. Dunford and Stephen T. HolgateAbstractIntroductionHistamine in the Asthmatic AirwayPhysiologic Role for Histamine in Lung and AsthmaImmunological Modulation by