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System podawania leków do oka in situ

System podawania leków do oka in situ

Akash Nanaware / Pooja Shah

71,96 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786630365719
71,96 €
IVA incluido
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Celem niniejszego badania było opracowanie i ocena termorewersyjnego hydrożelu do stosowania in situ w oku, zawierającego chloramfenikol, w celu wydłużenia czasu przebywania przed rogówką oraz poprawy biodostępności w oku. Preparat przygotowano z wykorzystaniem poloksameru 407 jako termoczułego polimeru żelującego oraz HPMC lub Carbopolu 940 jako środków zwiększających lepkość. Przygotowane preparaty scharakteryzowano pod kątem wyglądu, pH, właściwości reologicznych, temperatury żelowania, zawartości leku, uwalniania leku in vitro, aktywności przeciwbakteryjnej oraz stabilności. Spośród opracowanych preparatów partia F4 zawierająca 12% poloksameru 407 i 0,5% HPMC wykazała optymalne właściwości fizykochemiczne, odpowiednie zachowanie podczas żelowania, przedłużone uwalnianie leku oraz skuteczną aktywność przeciwbakteryjną. Wyniki te wskazują, że opracowany hydrożel in situ stanowi obiecujący oftalmiczny system dostarczania leku, zapewniający przedłużoną skuteczność terapeutyczną chloramfenikolu.

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